An Actin Filament Population Defined by the Tropomyosin Tpm3.1 Regulates Glucose Uptake
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An Actin Filament Population Defined by the Tropomyosin Tpm3.1 Regulates Glucose Uptake
Actin has an ill-defined role in the trafficking of GLUT4 glucose transporter vesicles to the plasma membrane (PM). We have identified novel actin filaments defined by the tropomyosin Tpm3.1 at glucose uptake sites in white adipose tissue (WAT) and skeletal muscle. In Tpm 3.1-overexpressing mice, insulin-stimulated glucose uptake was increased; while Tpm3.1-null mice they were more sensitive to...
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ژورنال
عنوان ژورنال: Traffic
سال: 2015
ISSN: 1398-9219,1600-0854
DOI: 10.1111/tra.12282